AOD-9604 5mg

Once-daily subcutaneous protocol for lipolysis research without IGF-1 elevation.

AOD-9604 5mg

AOD-9604 dosage protocols leverage this synthetic 16 amino acid fragment (Tyr-hGH 177-191) to support lipolysis (fat breakdown) and inhibit lipogenesis (fat storage) without elevating IGF-1 levels or causing insulin resistance.

Vial Size
Dose Range
Schedule
Primary Goal
5mg vial 300 to 500 mcg daily with gradual titration. Daily subcutaneous injections for 8 to 12 weeks (extend to 16 weeks if desired). Support reduction of fat mass and enhance fat oxidation over time.

Reconstitution Summary

0.5 mL per 5 mg vial (10 mg/mL).

Storage Summary

Lyophilized frozen; reconstituted refrigerated; avoid freeze-thaw.
AOD-9604 5mg
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AOD-9604 5mg

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Reconstitution Steps

  1. Draw 0.5 mL bacteriostatic water with a sterile syringe.
  2. Inject slowly down the vial wall; avoid foaming.
  3. Gently swirl until dissolved (do not shake).
  4. Label and refrigerate at 2 to 8 °C, protected from light. At 10 mg/mL, 1 unit = 0.01 mL » 100 mcg on a U-100 insulin syringe.

How It Works

AOD-9604 is a modified C-terminal fragment of human growth hormone that retains the lipolytic (fat-reducing) domain without the growth-promoting effects. It binds to adipose tissue and triggers breakdown of stored fat while blocking new fat storage (re-esterification) in adipocytes. At the molecular level, chronic AOD-9604 administration upregulates b3-adrenergic receptors in fat tissue, reversing obesity-related suppression of these fat-burning receptors. Unlike full-length hGH, AOD-9604 does not meaningfully elevate IGF-1 levels or worsen glucose tolerance, making its tolerability indistinguishable from placebo in human trials.

Benefits & Side Effects

  • Supports reductions in fat mass and increases in fat oxidation over time; clinical trials showed modest but
    statistically significant weight loss (approximately 2.6 kg vs. 0.8 kg placebo over 12 weeks at 1 mg/day).
  • Preferential loss of abdominal fat observed, resembling the pattern seen with low-dose hGH therapy.
    Does not meaningfully raise IGF-1 and shows a placebo-like safety profile in human studies; no
    anti-AOD9604 antibodies detected.
  • Emerging regenerative potential: preclinical studies suggest possible cartilage repair and bone health
    benefits.
  • Generally well tolerated; occasional mild injection-site reactions (redness, itch) may occur with
    subcutaneous administration.

References & Scientific Literature

  1. Safety and metabolism of AOD9604 as a nutraceutical ingredient (J Endocrinol Metab, 2014).
  2. Safety and tolerability of AOD9604 in humans; placebo-like safety profile (J Endocrinol Metab, 2013).
  3. Effects of hGH and AOD9604 on lipid metabolism in obese mice (Endocrinology / OUP).Drug treatment
  4. of the overweight patient; AOD-9604 RCT summary (Gastroenterology)