GHK-CU

Once-daily subcutaneous educational protocol for skin rejuvenation, collagen synthesis, wound healing, and

GHK-CU

tissue repair. GHK-Cu dosage protocols utilize this naturally occurring copper-binding tripeptide (glycyl-L-histidyl-L-lysine) to support skin rejuvenation, wound healing, and tissue repair. GHK-Cu stimulates collagen and elastin production, promotes angi

Vial Size
Dose Range
Schedule
Primary Goal
50 mg vial 1 to 2 mg daily with gradual titration. Daily subcutaneous injections, 5 days on / 2 days off, for 8 to 12 weeks. Support skin rejuvenation, collagen synthesis, wound healing, and anti-aging tissue repair.

Reconstitution Summary

2.5 mL per 50 mg vial (20 mg/mL) for accurate unit measurements.

Storage Summary

Lyophilized frozen at -20 °C; reconstituted refrigerated; use within 30 days.
GHK-CU 50mg
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GHK-CU 50mg

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Reconstitution Steps

  1. Draw 2.5 mL of bacteriostatic water with a sterile syringe.
  2. Inject slowly down the vial wall; avoid foaming.
  3. Gently swirl or roll until dissolved (do not shake).
  4. Label and refrigerate at 2 to 8 °C, protected from light; use within 30 days. At 20 mg/mL, 1 unit = 0.01 mL » 200 mcg on a U-100 insulin syringe.

How It Works

GHK-Cu functions as a signal peptide that triggers tissue repair processes by chelating copper(II) ions and delivering this essential trace metal to cells in a bioavailable form. Copper is a critical cofactor for enzymes involved in collagen synthesis (lysyl oxidase) and antioxidant defense (superoxide dismutase). Genomic studies show GHK-Cu modulates over 30% of human genes toward a regenerative, anti-aging phenotype. The peptide stimulates production of VEGF and bFGF in fibroblasts, promoting angiogenesis and blood flow to injured tissue. GHK-Cu also recruits immune cells to injury sites, increases collagen, elastin, and glycosaminoglycan synthesis, and regulates matrix metalloproteinases for balanced tissue remo

Benefits & Side Effects

  • Skin Rejuvenation: Clinical studies show increased skin thickness, improved dermal collagen density,
    and reduced wrinkle depth.
  • Wound Healing: Promotes angiogenesis, granulation tissue formation, and accelerated wound closure
    in preclinical models.
  • Anti-Inflammatory: Suppresses pro-inflammatory cytokines (TNF-alpha, IL-6) and provides antioxidant
    protection.
  • Hair Growth: Observed to enlarge hair follicle size and increase growth rate in studies.
    Safety Profile: Excellent tolerability with no serious adverse effects noted; extremely wide safety margin
    in toxicology studies.
  • Occasional mild injection-site reactions (transient redness or stinging) may occur with subcutaneous
    administration.

References & Scientific Literature

  1. Pickart L. The human tripeptide GHK and tissue remodeling (review).
  2. Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration.