CJC-1295 no DAC 5mg+ Ipa 5mg
CJC-1295 no DAC 5mg+ Ipa 5mg
Once-daily subcutaneous protocol for synergistic GHRH + GHS pulsatile GH research. This blend combines CJC-1295 (no DAC), a modified growth hormone-releasing hormone (GHRH) analog, with Ipamorelin, a selective growth hormone secretagogue (GH
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Vial Size
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Dose Range
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Schedule
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Primary Goal
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| 5 mg + 5 mg | 100 to 300 mcg of each peptide daily with gradual titration | Daily subcutaneous injections for 8 to 12 weeks (extend to 16 weeks if desired). | Support pulsatile GH release through synergistic GHRH + GHS stimulation. |
Reconstitution Summary
Storage Summary
Reconstitution Steps
- Draw 2 mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall; avoid foaming.
- Gently swirl until dissolved (do not shake).
- Label and refrigerate at 2 to 8 °C, protected from light. At 5 mg/mL total (2.5 mg/mL each), 1 unit = 0.01 mL » 50 mcg total, 25 mcg each peptide, on a U-100 insulin syringe.
How It Works
CJC-1295 (no DAC) is a modified GHRH analog (tetrasubstituted 29 amino acid peptide) that stimulates pulsatile GH release from the pituitary. Human studies demonstrate sustained, dose-dependent increases in both GH and IGF-1 with subcutaneous administration. Ipamorelin is a pentapeptide GH secretagogue with a half-life of approximately 1.5 to 2.5 hours that elicits a rapid GH pulse peaking around 40 minutes post-dose. Importantly, Ipamorelin selectively increases GH without affecting ACTH, cortisol, or prolactin levels. When combined, these peptides may produce synergistic GH release by acting on complementary receptor pathways.
Benefits & Side Effects
Observations from preclinical and clinical literature.
- Supports sustained GH and IGF-1 elevation through pulsatile release patterns.
- Ipamorelin demonstrates selective GH release without cortisol or ACTH elevation.
- Once-daily dosing of CJC-1295 (no DAC) has been shown to normalize growth in animal models.
- Generally well tolerated; possible transient effects may include flushing, headache, or injection-site
reactions. - Some individuals report increased appetite, water retention, or tingling sensations.
References & Scientific Literature
- Prolonged stimulation of GH and IGF-1 secretion by CJC-1295 in healthy adults (PubMed).
- Once-daily CJC-1295 normalizes growth in GHRH knockout mouse (PubMed).
- Raun K et al. Ipamorelin, the first selective growth hormone secretagogue (PubMed).
- Pharmacokinetic-pharmacodynamic modeling of ipamorelin in human volunteers (PubMed).