CJC-1295 no DAC 5mg+ Ipa 5mg

Support pulsatile GH release through synergistic GHRH + GHS stimulation.

CJC-1295 no DAC 5mg+ Ipa 5mg

Once-daily subcutaneous protocol for synergistic GHRH + GHS pulsatile GH research. This blend combines CJC-1295 (no DAC), a modified growth hormone-releasing hormone (GHRH) analog, with Ipamorelin, a selective growth hormone secretagogue (GH

Vial Size
Dose Range
Schedule
Primary Goal
5 mg + 5 mg 100 to 300 mcg of each peptide daily with gradual titration Daily subcutaneous injections for 8 to 12 weeks (extend to 16 weeks if desired). Support pulsatile GH release through synergistic GHRH + GHS stimulation.

Reconstitution Summary

2 mL per 10 mg vial (5 mg/mL total, 2.5 mg/mL each peptide).

Storage Summary

Lyophilized frozen; reconstituted refrigerated; avoid repeated freeze-thaw.
CJC-1295 no DAC 5mg+ Ipa 5mg
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CJC-1295 no DAC 5mg+ Ipa 5mg

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Reconstitution Steps

  1. Draw 2 mL bacteriostatic water with a sterile syringe.
  2. Inject slowly down the vial wall; avoid foaming.
  3. Gently swirl until dissolved (do not shake).
  4. Label and refrigerate at 2 to 8 °C, protected from light. At 5 mg/mL total (2.5 mg/mL each), 1 unit = 0.01 mL » 50 mcg total, 25 mcg each peptide, on a U-100 insulin syringe.

How It Works

CJC-1295 (no DAC) is a modified GHRH analog (tetrasubstituted 29 amino acid peptide) that stimulates pulsatile GH release from the pituitary. Human studies demonstrate sustained, dose-dependent increases in both GH and IGF-1 with subcutaneous administration. Ipamorelin is a pentapeptide GH secretagogue with a half-life of approximately 1.5 to 2.5 hours that elicits a rapid GH pulse peaking around 40 minutes post-dose. Importantly, Ipamorelin selectively increases GH without affecting ACTH, cortisol, or prolactin levels. When combined, these peptides may produce synergistic GH release by acting on complementary receptor pathways.

Benefits & Side Effects

Observations from preclinical and clinical literature.

  • Supports sustained GH and IGF-1 elevation through pulsatile release patterns.
  • Ipamorelin demonstrates selective GH release without cortisol or ACTH elevation.
  • Once-daily dosing of CJC-1295 (no DAC) has been shown to normalize growth in animal models.
  • Generally well tolerated; possible transient effects may include flushing, headache, or injection-site
    reactions.
  • Some individuals report increased appetite, water retention, or tingling sensations.

References & Scientific Literature

  1. Prolonged stimulation of GH and IGF-1 secretion by CJC-1295 in healthy adults (PubMed).
  2. Once-daily CJC-1295 normalizes growth in GHRH knockout mouse (PubMed).
  3. Raun K et al. Ipamorelin, the first selective growth hormone secretagogue (PubMed).
  4. Pharmacokinetic-pharmacodynamic modeling of ipamorelin in human volunteers (PubMed).