CJC-1295 DAC 5mg
CJC-1295 DAC 5mg
CJC-1295 DAC is a long-acting synthetic analog of growth hormone-releasing hormone (GHRH). The DAC (Drug Affinity Complex) modification binds reversibly to albumin, extending the peptide's half-life to approximately 6 to 8 days
|
Vial Size
|
Dose Range
|
Schedule
|
Primary Goal
|
|---|---|---|---|
| 5mg vial | 300 to 1,000 mcg per injection with gradual titration. | Twice-weekly subcutaneous injections for 8 to 12 weeks (extend to 16 weeks if desired). | Support sustained GH and IGF-1 elevation for research into GH-axis effects. |
Reconstitution Summary
Storage Summary
Reconstitution Steps
- Draw 0.5 mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall; avoid foaming.
- Gently swirl until dissolved (do not shake).
- Label and refrigerate at 2 to 8 °C, protected from light. At 10 mg/mL, 1 unit = 0.01 mL = 25 mcg on a U-100 insulin syringe.
How It Works
CJC-1295 DAC mimics endogenous GHRH, binding to GHRH receptors on pituitary somatotrophs to drive GH release. The DAC modification (albumin-binding moiety) keeps the GHRH analog circulating for days rather than minutes, extending the half-life to approximately 6 to 8 days. The resulting GH surge stimulates IGF-1 production (primarily in the liver); IGF-1 then mediates many growth and metabolic effects through JAK/STAT signaling pathways. Notably, pulsatile GH secretion persists even during continuous CJC-1295 stimulation, preserving physiological release patterns.
Benefits & Side Effects
- Supports sustained elevation of GH and IGF-1 in a dose-dependent manner.
- May promote increased lean body mass, reduced fat mass, and improved body composition consistent
with GH/IGF-1 axis activation. - Enhanced protein synthesis and recovery potential through anabolic signaling.
Generally well tolerated in clinical studies; occasional mild injection-site reactions (redness, swelling)
may occur. - Some individuals report transient flushing, headache, or water retention during initial ti
References & Scientific Literature
- Teichman SL et al. Prolonged stimulation of GH and IGF-1 by CJC-1295 in healthy adults (J Clin Endocrinol Metab, 2006).
- Ionescu M et al. Pulsatile GH secretion persists during continuous CJC-1295 stimulation (J Clin Endocrinol Metab, 2006).
- Alba M et al. Once-daily CJC-1295 normalizes growth in GHRH knockout mouse (Am J Physiol Endocrinol Metab, 2006).
- Brinkman JE et al. Physiology, Growth Hormone (StatPearls, NCBI Bookshelf).