GHRP-2 5mg
GHRP-2 5mg
GHRP-2 (Growth Hormone-Releasing Peptide-2) is a synthetic hexapeptide that stimulates potent, dose-dependent growth hormone release by activating ghrelin receptors. Clinical studies predominantly employ once-daily subcutaneous administration.
|
Vial Size
|
Dose Range
|
Schedule
|
Primary Goal
|
|---|---|---|---|
| 5mg vial | 100 to 300 mcg daily with gradual titration; higher doses show dose-dependent responses but may offer limited added benefit with routine use. | Daily subcutaneous injections for 8 to 12 weeks (extend to 16 weeks if desired). | Stimulate endogenous growth hormone secretion through ghrelin receptor activation. |
Reconstitution Summary
Storage Summary
Reconstitution Steps
- Draw 0.5 mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall; avoid foaming.
- Gently swirl or roll until completely dissolved (do not shake).
- Label and refrigerate at 2 to 8 °C, protected from light. At 10 mg/mL, 1 unit = 0.01 mL » 100 mcg on a U-100 insulin syringe.
How It Works
GHRP-2 is a synthetic growth hormone secretagogue that binds to and activates ghrelin (GH secretagogue) receptors. This activation triggers potent, pulsatile release of growth hormone from the pituitary gland in a dose-dependent manner. Clinical studies in GH-deficient children demonstrated meaningful GH increases even at low doses (0.3 to 3.0 mcg/kg), with escalating doses over several months showing sustained efficacy. In healthy adults, doses of 100 mcg SC daily produce acute GH stimulation, while routine protocols typically maintain 100 to 300 mcg/day to balance efficacy with receptor sensitivity. The peptide has been well tolerated in clinical trials with no significant adverse effects or toxicity reported at these dosage range
Benefits & Side Effects
- Stimulates robust pulsatile GH release that may support favorable body composition changes and
metabolic effects. - In combination therapies (e.g., with GHRH analogs), can significantly increase IGF-1 levels when
administered with perfect compliance. - Generally well tolerated with placebo-like safety profile; transient side effects may include mild hunger
sensation or flushing. - Long-term therapy (8 to 24 months in GH-deficient subjects) has maintained positive effects on growth velocity with careful monitoring.
Occasional mild injection-site reactions (redness, irritation) may occur with subcutaneous administration.
References & Scientific Literature
- Effects of GHRP-2 on GH release and growth performance (Domestic Animal Endocrinology).
- Effects of eight months treatment with graded doses of GHRP-2 in GH-deficient children (J Clin Endocrinol Metab).
- Five-day treatment with daily subcutaneous GHRP-2: response attenuation and IGF-I effects in healthy young men (Eur J Endocrinol).
- GH/IGF-1 response to acute and chronic GHRP-2, GHRH 1-44, and their combination in older adults (Endocrine)