Epithalon 10mg
Epithalon 10mg
Epitalon (Epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed from pineal gland research for its geroprotective potential. Epitalon activates telomerase to promote telomere elongation, supports healthy melatonin production
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Vial Size
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Dose Range
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Schedule
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Primary Goal
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| 10 mg vial | Daily subcutaneous injections for 20 consecutive days, followed by 4 to 6 months off-cycle. Dose: 5,000 mcg (5 mg) daily. | Support telomere maintenance, melatonin regulation, and geroprotective effects over time. |
Reconstitution Summary
Storage Summary
Epithalon 10mg
Reconstitution Steps
- Draw 1 mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall; avoid foaming.
- Gently swirl until dissolved (do not shake).
- Label and refrigerate at 2 to 8 °C, protected from light. At 10 mg/mL, 1 unit = 0.01 mL = 50 mcg on a U-100 insulin syringe.
How It Works
Epitalon’s primary mechanism involves telomerase activation, promoting telomere elongation in cells. In vitro studies demonstrated that Epitalon induced telomerase and lengthened telomeres in human cell cultures, allowing cells to continue dividing beyond the usual Hayflick limit. Epitalon also influences the neuroendocrine system by stimulating nocturnal melatonin release from the pineal gland, thereby normalizing circadian hormone rhythms in aged subjects. Additional reported effects include antioxidant activity, genomic regulatory effects, and immune modulation.
Benefits & Side Effects
- Supports telomere maintenance and cellular longevity through telomerase activation.
- Restores healthy melatonin production and circadian rhythm regulation.
- Extended lifespan and reduced tumor incidence observed in animal models.
- Human trials showed improved cardiovascular outcomes and reduced mortality over 12-year follow-up.
- Generally well tolerated; no serious adverse events reported in long-term studies.
Occasional mild injection-site reactions or transient sleep pattern changes may occur.
References & Scientific Literature
- Overview of Epitalon: Highly Bioactive Pineal Tetrapeptide with Promising Properties (Int J Mol Sci, 2025).
- Epitalon increases telomere length in human cell lines through telomerase upregulation (Biogerontology).
- Synthetic tetrapeptide Epitalon restores neuroendocrine regulation in senescent monkeys (Neuroendocrinology Letters).
- Geroprotective effect of epithalamine in elderly with accelerated aging (12-year RCT, Bull Exp Biol Med).